How do cocaine self-administration and incubation influence Ca²⁺ activity in cholinergic interneurons (CINs)?

How does cocaine alter translational control in cholinergic interneurons (CINs)?

How does cholinergic interneuron (CIN) activity regulate fundamental aspects of motivated behavior, such as reward seeking, cue salience, and the liking/wanting of rewards?

How do different temporal patterns of cocaine self-administration, intermittent (IntA) versus long access (LgA), differentially affect striatal circuit activity and cell-type–specific translational responses underlying addiction-like behavior?

How does intermittent-access (IntA) polysubstance self-administration of cocaine and alcohol influence choice behavior and neural plasticity compared to cocaine alone?

Endless questions. Focused curiosity!